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Store unopened semaglutide in the refrigerator at 36F to 46F (2C to 8C), away from the freezer compartment and cooling elements

Semaglutide is set to lose patent protection across multiple markets in 2026, including Canada, India, China, Brazil and Turkey - regions that together account for roughly a third of the worlds adult obese population

The MannWhitney U test was employed to compare among different stages and also among different groups

It is best not to use a medication after its expiration date or if it has not been properly stored

SURMOUNT-5, published in the New England Journal of Medicine, directly compared the maximum tolerated doses of tirzepatide and semaglutide in the same patient population

The FDA-approved titration schedule starts at a low dose (0.25 mg weekly for Ozempic or Wegovy) to minimize gastrointestinal side effects, gradually increasing every four weeks