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Hematologic Toxicities Hematologic side effects are most pronounced with cytotoxic oral agents such as temozolomide, etoposide, and cyclophosphamide , which target rapidly dividing hematopoietic precursors in the bone marrow

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Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

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doi: 10.1016/j.pathophys.2006.05.007 17 ChauhanA.ChauhanV.BrownW