Although the precise molecular mechanisms remain unclear, it has been proposed that complex II inhibition helps to maintain mitochondrial redox balance and supports mitochondrial energy metabolism
They act on GLP-1 receptors in the pancreas (insulin secretion, glucagon suppression), hypothalamus (appetite suppression via POMC/NPY pathways), gastric smooth muscle (delayed emptying), and peripheral tissues including adipose and immune cells
The new review suggests there is no evidence of harm and some evidence of benefit, but the evidence base remains limited and the drugs remain unapproved for this specific use
Zaugg, K
ArGLP-1 con indicacin para obesidad Como se ha adelantado, existen dos arGLP-1 indicados para el tratamiento de la obesidad en la UE, en sujetos con IMC 30 kg/m2, o con IMC 27 kg/m2, y al menos una comorbilidad relacionada con el peso, siempre en combinacin con una dieta apropiada y ejercicio fsico: liraglutida 3 mg y semaglutida 2,4 mg
IGF-1 can assist the reproductive organs with repairing themselves after stress or injury