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Approvals in metabolic liver disease and cardiovascular risk reduction reinforce their role as cardiometabolic therapies

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39 Based on its recent discovery, the relevant role of mNADK in human cancers still need to be clarified, but the wild-type and mutant cNADK are potential clinical targets for cancer therapy

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That protein is known for its inhibitory properties in muscle production and growth due to its historic relation to the activin type IIB receptor (ActRIIB), achieving said repression by increasing the Smad 2/3-mediated transcription

Nature 503 , 277280 (2013)