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In addition, low SHBG levels may reflect increased androgen binding, which reduces circulating and central androgen levels and potentially increases central IR, contributing to neurological damage [181]

Ru II -02 suppressed DPPIV activity more potently ( K i = 20.2 0.8 M) than Ru II -01 , Ru II -03 , or free curcumin

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In addition, many alcoholics suffer from malnutrition, which can lead to liver damage and impaired liver function