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The word unimolecular is important: rather than combining two separate drugs, survodutide is a single molecule whose sequence has been tuned so that one peptide backbone can activate both receptors with a deliberately calibrated balance of potency

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A network meta-analysis found that adverse events were more frequent with retatrutide (relative risk 4.10) compared to tirzepatide (relative risk 2.78)

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Nanodiscs in Membrane Biochemistry and Biophysics