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Retrieved May 7, 2008

Inhibition of COX-2 by NSAIDs blocks PG production at sites of inflammation, whereas inhibition of COX-1 in other tissues (platelets and the gastroduodenal mucosa) leads to common adverse effects of NSAIDs, such as bleeding and gastrointestinal ulceration ( Owing to the adverse effects of NSAIDs and corticosteroids, disease-modifying antirheumatic drugs (DMARDs), a class of immunosuppressive and immunomodulatory agents, are developed to prevent and relieve RA aggression

Hirsch GE, Jaskulski M, Hamerski HM, Porto FG, da Silva B, Aita CAM, et al

These will increase glutathione levels in the body which can likewise render the treatments ineffective