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This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]

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If possible, your therapist will encourage you to avoid repetitive hand motions such as heavy grasping, wringing, as well as turning and twisting movements of the wrist

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49 Elevated inflammatory factors in T2D such as IL-6 and interferon- (IFN-) cand bind to their receptors, activate JAK2/STAT3, subsequently upregulates the expression of suppressor of cytokine signaling 3 (SOCS3), which inhibit IRS-1 cascade