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[5] [11] Some sleep difficulties reported during trials may therefore reflect the underlying condition rather than a direct drug effect

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In addition, the oxidants may also originate from cytosolic enzyme systems, e.g., NADPH oxidases, and from exogenous triggers such as ionizing radiation and chemotherapeutics

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SGLT-2 inhibitors significantly reduced cardiovascular (RR = 0.88) and total (RR = 0.87) death, as compared with DPP-4 inhibitors, while GLP-1 RA reduced total death only (RR = 0.87)