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Plasma and tissue GSH levels decline with age, while markers of oxidative damage increase, creating a "redox imbalance" implicated in the pathogenesis of age-related diseases [2][3][10][11]

C., Zanin, C

10.1371/journal.pone.0226927 PLoS One

Although initially Klotho expression was found only in the distal tubule, it has subsequently been demonstrated to occur in the proximal tubule as well