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Dysbiosis, characterized by an imbalance of beneficial and harmful microbes, may contribute to inflammation, DNA damage, and tumorigenesis in the colon

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These targeted signaling molecules are either part of a signaling cascade, or transcription factor, or an enzyme that further generates signaling mediators (e -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner