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In this experiment, calibrated Von Frey filaments were employed to evaluate joint pain sensitivity as previously described 38,39 , the results showed that metformin treatment increased the paw withdrawal thresholds compared with those in MIA-induced OA model group (Fig

doi: 10.1034/J.1399-3038.2002.00010.X 236 RosenlundHMagnussonJKullIHkanssonNWolkAPershagenGet al

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Ick +/ mice compared with that in Mak / mice (Fig 3E)

Result: a larger GH pulse than GHRH alone

Other avenues explored to reduce fibroid size include anti-inflammatory drugs, such as N-acetylcysteine (NAC) (Phase III) and anti-cholesterol drugs like simvastatin (Phase II)