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Insufficient oxygen supply constitutes the core pathophysiological basis for high altitude illnesses

The 3-week mark seems to be a common turning point

RNA isolation and qRT-PCR Total RNA from the tissues and cells was extracted using the TRIzol method (Takara, Japan)

Grave de Peralta Menendez R, Murray MM, Michel CM, Martuzzi R, Gonzalez Andino SL (2004)

This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes

Browning F