Long-term safety data are lacking, and as with other peptides affecting tissue remodeling, theoretical concerns about promoting abnormal cell growth exist
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Saratale RG, Benelli G, Kumar G, Kim DS, Saratale GD
1 In silico analysis of the impact of R152H mutation on GPX4 (GPX4 U46C PDB: 2OBI) structure
GSH levels in macrophages, directly affect the Th1/Th2 cytokine response, and more specifically, GSH depletion inhibits Th1-associated cytokine production and/or promotes Th2 associated responses (Fraternale et al., 2006)
Besides, GLP-1R agonists also regulated PC12 cells growth through regulating cAMP/PKA signaling pathway (212)