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The peptide stimulates egr-1 gene expression and induces nab2 repressor, creating a negative feedback loop that appears central to its healing effects in cardiovascular, liver, and brain pathologies

Avoid mixing it in the same routine with strong direct acids, retinoids, or strong vitamin C formulas , since commercial copper-peptide products commonly advise against that pairing

Scherz-Shouval, R

\Modern Formulations Available: Newer, concentrated versions are being developed to support its use

They've got a total of 11 ingredients in common

CD44 was also reported to be upregulated in cholangiocytes associated with epithelial to mesenchymal transition 45 , in cholangiocarcinoma 46 and cholangiopathies 47 including in PSC patients 48,49