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Loss of DJ-1 increases ROS production, mitochondrial damage, autophagy, and mitophagy, accompanied by downregulation of Nrf2 and ARE genes (72, 119)

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Inhibition of transcriptional activity of c-JUN by SIRT1

This experience underscores how difficult it is to predict the potential for vaccine-induced antibodies or a therapeutic antibody to enhance the severity of disease, because other mechanisms of pathogenesis that result in severe disease are potentially involvedeven for the well-studied case of dengue

Dental abscesses in upper molars can radiate pain to the ear through the trigeminal nerve, often accompanied by tooth sensitivity to hot/cold and facial swelling on the affected side

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