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Although each model differs in terms of CAG repeat length and transgene expression levels, and thus in the severity of the resulting HD phenotype, they were instrumental in demonstrating a fundamental feature of the disease, namely that severe neuronal dysfunction precedes degeneration and it is probably the primary cause of many HD symptoms 8,9

C., Moore, E

2024 Jul 23;51(1):835

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FDA then advances research in those scientific areas and publishes annual reports describing the corresponding activities and outcomes