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The figure: Renal GLP1R/Glp1r is expressed in human and murine vascular smooth muscle cells (VSMCs) and Glp1rVSM-/- mice have reduced Glp1r transcripts in renal tissues

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The rats received doses of KBP-089 (KBP) (0.625, 1.25 and 2.5 g/kg sc), liraglutide (L) (200 and 400 g/kg sc) and the combinations (KBP 0.625 + L 200 g/kg, KBP 0.625 + L 400 g/kg, KBP 1.25 + L 200 g/kg, KBP 1.25 + L 400 g/kg and KBP 2.5 + L 200 g/kg, KBP 2.5 + L 400 g/kg) and vehicle (saline) for 9 weeks

Grip strength, walking speed, and functional performance are clinically more meaningful than absolute LBM numbers from a DXA scan