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Enrichment significances were set to a false discovery ratio (FDR) 5%

When cyp2e1 knockout mice that lack the ability to produce the CYP2E1 enzyme were challenged with acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this CYP is the principal enzyme responsible for the metabolic conversion of the drug acetaminophen to its active hepatotoxic metabolite NAPQI (Figure 2)

[PMID:34606698] Takeoka Y, Matsumoto K, Taniguchi D, et al

Guo S, Huang Z, Zhu J, Yue T, Wang X, Pan Y, et al

Be wary of products that promise "instant" results or are sold via unregulated channels, as these may not meet the safety standards required by the Ministry of Health (KKM)

In certain instances, the penetration enhancing agent is a hyaluronidase