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In vitro experiments of western blotting indicated that the expression of GLP-1R in chondrocytes treated with LPS significantly decreased, while the expression levels of STING, ACSL4, and IL-6 significantly increased

This lignans profile suggests it primarily aids in controlling the neuroinflammatory environment in PD, which is an important aspect of slowing neurodegeneration

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In addition, treatment with 5-FU or AZ628 led to an increase in the intracellular levels of ferrous iron, as measured by confocal and flow cytometry of FeRhoNox-1 staining ( Figures 4E, F , and Supplementary Figures S3C, D )