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Research protocols using CJC-1295/Ipamorelin maintain efficacy beyond 12 months with no receptor downregulation, while MK-677 shows IGF-1 plateau in some subjects after 69 months of daily dosing

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J Toxicol Clin Toxicol 22(1):3149 Madejczyk MS, Aremu DA, Simmons-Willis TA, Clarkson TW, Ballatori N (2007) Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein

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C.BiondaniP.MaggiC.GariboldiM.GloghiniA.InnoA.et al (2013)