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GLP-1s: What They Do (and Dont Do) How they work: GLP-1 receptor agonists mimic a gut hormone that slows gastric emptying, increases satiety, and regulates blood sugar

Maintenance can be as little as a few months to forever

Leptin resistance is common in obesity and adds to difficulty losing weight and keeping weight loss

2015;309:E100818

Oral administration of rhein (150 mg/kg in water) for 40 days significantly increased energy expenditure, reduced body weight, particularly body fat content, improved insulin resistance, and lowered circulating cholesterol levels in DIO mice

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