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Cardiomyocyte apoptosis and cardiac fibrosis were increased in the mouse model of diabetic cardiomyopathy, the protein expression of Nrf2 and HO-1 was reduced in left ventricular cardiomyocytes

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[61] They were examining hormones secreted during eating, and testing them on pig pancreases, leading to the discovery of GLP-1's significant effects in 1988

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