12 Cellular swelling, karyolysis, karyorrhexis, vacuolization, inflammation and release of cellular contents (alanine aminotransferase, ALT) are key processes of hepatocyte necrosis and related death in humans, as shown by the biochemical evidence of severe elevations in aminotransferases, especially ALT
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Indeed, other tissues from the Gclc KO mice, including the kidney, pancreas, and spleen, were also histologically similar to tissues from the Gclc WT mice (Fig
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doi:10.1016/S0021-9258(19)77815-6
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