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Research has examined GIPR-specific biological contributions using Tirzepatide alongside selective GIPR antagonist controls characterising GIPR-driven insulin secretory potentiation, GIPR-mediated adipocyte biology including direct fat depot lipid metabolism effects, GIPR expression and signalling in hypothalamic appetite circuits, and the GIPR biology underlying Tirzepatides superior weight reduction relative to GLP-1R monoagonism
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About this article Cite this article Wei, X., Buse, J.B., Chen, H
Genetics, appetite regulation, metabolism, fat storage, energy expenditure, GLP-1, GIP, leptin, ghrelin, and insulin may influence weight regulation
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