According to the Zepbound label, the most frequent include nausea (24-29%), diarrhea (18-24%), vomiting (8-10%), and constipation (16-17%)
These results highlight semaglutides early action on decreasing major cardiovascular events, with significant benefits already evident by the first six months, and for some, even earlier, even before any major weight loss and before most patients would have been titrated to their full target dose of 2.4 mg, lead author Jorge Plutzky, MD, director of preventive cardiology with Brigham and Womens Hospital, said in a statement
Patients may start to notice a reduction in their appetite within the first few days or weeks of treatment
Escalation: If tolerated, the dose is increased to the next level (e.g., 7 mg, then 14 mg) every 4 weeks
Individuals who feel low on energy , especially during workouts or stressful days
The GLP-1 receptor activation that reduces appetite also slows gastric motility, which causes the sensation of fullness and sometimes nausea