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doi: 10.1093/brain/awp296 128 WillisSNStadelmannCRodigSJCaronTGattenloehnerSMallozziSSet al

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Finally, we discuss whether the inhibition of tryptophan hydroxylase (TPH), in particular the neuronal isoform (TPH2), may provide an opportunity to pharmacologically target central 5-HT synthesis, and so develop new treatments for severe, life-threatening SS