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In: Lajtha A, Oja SS, Saransaari P, Schousboe A (eds) Handbook of neurochemistry and molecular neurobiology

REDEFINE 2 (Type 2 Diabetes) In patients with T2D, CagriSema produced significant weight loss alongside glycemic improvements (HbA1c reduction), outperforming the individual components (Lingvay et al., 2025)

PMID: 32257855

This flexibility is especially important for patients who may tolerate one component better than the other or who require different dose ratios than those available in Qsymia

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Appreciation of these issues will determine whether the results of an experiment are relevant for understanding mechanisms of cell death and identification of novel therapeutic targets for most patients or if they are clinically irrelevant and just adding background noise to the literature