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In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]

Brown, K

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Materials and Methods This study adhered to CONSORT guidelines and was approved by the Institutional Review Board at Nova Southeastern University in Fort Lauderdale, FL, USA

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