[119] fabricated a bilateral microneedle patch to deliver cyclodextrin-based metalorganic framework (CD-MOF)-encapsulated DXMS and paeonol to overcome the disadvantages of conventional intranasal administration, which not only enhanced the therapeutic effect of the drug but also reduced mast cell degranulation and modulated Th17/Treg cell homeostasis
95% CI, 1.06 to 1.21) compared to SGLT-2 inhibitor therapy with insulin [93]
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This crosstalk amplifies neuroinflammatory signaling and alters neurovascular integrity, contributing to blood-brain barrier disruption, glial priming, and neuronal injury 11-12
