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Apart from the score values, severe perivascular and brain tissue edema with brain congestion were the most distinct and characteristic findings

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Specifically, IGF-I can increase the number of CD4 + CD8 + immature T cells in rat thymus and spleen[162], promotes T cell survival[163], proliferation, chemotaxis and maturation, and blocks spontaneous and induced programmed cell death[163, 164], although it has also been reported to block IL-2-dependent lymphocyte growth and function[165]

Paoletti A, Pencharz PB, Ball RO, Kong D, Xu L, Elango R, Courtney-Martin G