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Pyruvate, -ketoglutarate, glutamate, and aspartate all stayed constant between the two groups (Figure 1)

Transfer learning for drug-target interaction prediction

While clinical trials adhere to standardised titration protocols to evaluate efficacy, clinical practice allows for a slower, individualised approach, particularly for patients experiencing early GI symptoms

While human clinical trial data remains limited, the consistency and reproducibility of animal model results provides substantial mechanistic understanding

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Continued vigilance is essential to support safe administration across heterogeneous cohorts