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Those APCs that violate the 2 times rule are identified and appear in Table 16

Similar economic benefits have been observed in other therapeutic areas where peptides provide superior clinical outcomes

A class of drugs called GLP-1 agonists, which includes Ozempic (semaglutide), has been used to treat type 2 diabetes for over a decade

Mitigation: Resistance training and high protein intake (1.6g to 2.2g per kg of body weight) are non-negotiable requirements to preserve muscle during treatment

Notably, older adults with obesity and preserved baseline muscle mass represent a particularly understudied phenotype, and dedicated studies are needed to determine whether this subgroup may differentially benefit from the muscle quality improvements associated with GLP-1 RA therapy

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