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Research applications may include copper peptide pathway models, skin matrix research, collagen pathway studies, extracellular matrix research, peptide-metal complex signaling analysis, cellular response models, matrix-associated signaling comparisons, and structure-function evaluation

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A more recent, larger study using iPSCs to create 2D cell lines and 3D organoids from 15 subjects with 22q11DS and 15 matched controls found transcriptional changes in 22q11DS neurons enriched for genes that increase risk for ASD and SSD

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