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The majority of data supports the notion that the most likely sources of transmission are person-to-person contact in families and/or exposure to a common source of infection such as contaminated water or food (14-16)

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Adv Exp Med Biol (2019) 1184:187203

Microbiota-derived phenylacetylglutamine associates with overall mortality and cardiovascular disease in patients with CKD

Gastrointestinal peptides bind to their receptors which are synthesized in the cell body of the NG neurons located in the neck and are transported to vagal afferent terminals in the gastrointestinal tract 11,12

However, it is not a substitute for lifestyle changes, which are also needed to help improve cardiovascular risk factors