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It impairs physical function and independence, particularly concerning for older adults

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Some patients experience symptom improvement due to overall weight loss and reduced food intake, while others report worsening nausea or bloating

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These effects may be optimally stimulated at lower concentrations where the body interprets the signal as a gentle prompt rather than an emergency

Given these findings, clinicians must carefully consider patient-specific conditions and potential risks when prescribing these medications to ensure optimal patient safety and rational drug use