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This section directly addresses the critical gap between animal research and established clinical efficacy
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Am J Neurosci 3(1):1724 Thirupurasundari CJ, Padmini R, Devaraj SN (2009) Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats
A variety of mechanisms are proposed to explain the anti-depressant potential of flavonoids, including modulation of the neurotransmitter system and regulation of dopaminergic, noradrenergic, and serotonergic pathways in the CNS or by neurotrophic factors, anti-inflammatory, etc (as summarized in Table 1)