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Medicare is prohibited by law from covering weight-loss drugs, but the Centers for Medicare and Medicaid Services is allowed to run short-term demonstration projects to test new payment and coverage models

For reproducibility, investigators pre-register endpoints, include blinding and randomization, and document supplier, lot, and COA to maintain traceability across cohortsan approach that supports transparent reporting while keeping the framing strictly preclinical and non-therapeutic

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and the Giorgio Foundation