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6B, C) in the presence of wild-type p53, although this effect was abolished by p53 knockdown

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Importantly, these pathological alterationsindicative of mitochondrial swelling and metabolic dysfunctionwere significantly attenuated by LEO treatment at both 30 and 60 mg/kg doses, with high-dose administration restoring near-normal ultrastructure

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Washington, DC: AARP Public Policy Institute

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Cancer Colorectal cancer Breast cancer Leukemia Lung cancer Prostate cancer The link to cancer risk is primarily through elevated homocysteine and impaired DNA repair mechanisms

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The antinociceptive effect of nicorandil was attenuated by NO/cGMP modulators, as evidenced by prior administration of the NO precursor, arginine and the phosphodiesterase inhibitor, sildenafil

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