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In contrast, multi-pathway blockade offers improved robustness against metabolic plasticity but inevitably increases formulation complexity and raises concerns regarding biosafety and pharmacokinetics

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2.4.7 Bioequivalence analysis An analysis of variance (ANOVA) of the main pharmacokinetic parameters ( C max , AUC 0-t , AUC 0- ) between three groups was performed using SPSS commercial software (version 26.0

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