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First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design
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What the clinical trial data shows Weight loss SURMOUNT-5 SURMOUNT-5 enrolled 751 adults with obesity but without type 2 diabetes and assigned them to the maximum tolerated dose of either tirzepatide (10 mg or 15 mg) or semaglutide (1.7 mg or 2.4 mg) for 72 weeks
Unmeasured confounders, particularly lifestyle factors such as dietary patterns, physical activity levels, smoking status, and alcohol consumption, could influence both treatment selection and observed ocular outcomes