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Several barriers must be overcome when developing orally administered peptides with a molecular weight above 1,000 Da, including enzymatic degradation in the GI tract, pH-induced conformational changes, limited permeability of the intestinal membrane, and variable GI tract absorption rates [2, 3, 42, 43]

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Compounded medications are often measured in milliliters (ml) or units in a syringe, whereas Wegovy is measured in fixed milligrams (mg) per pen

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Most patients refrigerate their tirzepatide at 3646F (28C), where the medication remains stable for specific durations depending on the compounding formulation