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Other studies have demonstrated successful rescue of neurological and electrophysiological deficits in adult Ube3a Stop/p+ mice after reactivation of the Ube3a gene and rescue of neurological defects in adult Mecp2 lox-Stop/y mice after reactivation of the Mecp2 gene [183,184,185]

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Based on the Certificate of Product Notification issued to the company, any subsequent changes to the information previously submitted to the FDA will render the notification invalid