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10.3904/kjim.2021.174 181 SuzanneM

In some individuals, prolonged use may contribute to gastroparesis, cyclic vomiting, or impaired nutrient absorption (25)

The researchers did outline several of the studys limitations, stating additional adjustments for potential confounders, such as alcohol or substance misuse, were limited by the relatively small number of reports found

Rectal tumour biopsies ( n =10) were collected from consenting patients undergoing diagnostic endoscopy, a baseline measurement of metabolic rate was recorded, biopsies were treated for 24 h with metformin (10 mM) or H 2 O vehicle control and metabolism was assessed at 24 h post treatment