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Notably, studies using glucagon receptordeficient (GCGR - / - ) mouse models have demonstrated that inhibiting glucagon action can ameliorate hyperglycemia even in the absence of insulin ( 5.2 Emerging roles in lipid and bile acid metabolism Beyond glycemic regulation, glucagon plays a multifaceted role in lipid and bile acid metabolism

GIPR is primarily expressed in pancreatic -cells, adipose tissue, the small intestine, and the central nervous system playing a key role in energy metabolism and nutrient homeostasis

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