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A 2023 analysis published in JAMA Network Open found that high out-of-pocket costs for GLP-1 receptor agonists were the primary driver of treatment discontinuation within the first 12 months, with 42.1% of commercially insured patients stopping therapy by month 12

The medication simultaneously activates receptors in the hypothalamus (your brain's appetite control center) and the nucleus tractus solitarius, both regions involved in energy expenditure regulation, not just hunger suppression

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This happens as your body adjusts to the medication

Research 4 has shown that semaglutide (Wegovy 2.4 mg) can lead to a weight loss of around 15% of your body weight after 68 weeks

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