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Outcome prediction using this nomogram cannot be applied to acetaminophen concentrations obtained outside this 20-hour window or with chronic or recurrent exposures

Once ingested or injected, niacinamide is converted to nicotinamide mononucleotide (NMN) and then to NAD+ through the salvage pathway

Depletion of GSH due to intensified oxidative stress or the action of inhibitors significantly reduces the ability of GPX4 to counteract lipid peroxidation, leading to increased lipid peroxides and subsequent ferroptosis (151)

10.1016/j.eplepsyres.2013.09.010 Epilepsy Res

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E., & Berge, K