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These expanded clinical uses drastically widen the addressable patient population

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Adrenal Insufficiency Inform patients that opioids could cause adrenal insufficiency, a potentially life- threatening condition

343 Reduced astrocytic homoeostatic support is also evidenced by the loss of endfeet polarisation of AQP4 344 and decreased expression of monocarboxylate transporter 1 345 responsive for lactate supply of neurones

61 , 15281532 (2009) Acknowledgements The study was supported by the National Institutes of Health (NIH), the National Institute of Neurological Disorders and Stroke (NINDS), and the Center for Neuroscience and Regenerative Medicine (CNRM) at the Uniformed Services University of the Health Sciencesa collaborative effort between the NIH, the Department of Defense and the Walter Reed National Military Medical Center to develop innovative approaches for brain injury diagnosis and recovery