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The pace and quality of this cycle are orchestrated largely by the dermal papilla , a cluster of specialized mesenchymal cells at the base of the follicle that signals to the surrounding matrix and stem-cell compartment

Klene, M

Timing depends on individual factors and protocols

Hormonal shifts (like menopause), inflammation, or even a salty meal can cause temporary water retention that masks fat loss

This dual mechanism, eating less while burning more, accounts for the superior weight loss outcomes observed in clinical trials

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