Beyond their metabolic actions, GLP-1RAs directly influence vascular tissues by reducing inflammation, oxidative stress, and endothelial activation, each of which contributes to plaque initiation and progression
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After transfer, membranes were blocked in 1% bovine serum albumin in PBS with 0.1% Tween-20 and probed with anti-PARP (NB100-56599, Novus Biologicals, Littleton, CO), anti-Glutathione (AB19534, Abcam, Cambridge, MA), anti-phospho-IB- (9246), anti-IB- (9242), anti-phospho-IKK- (2594), anti-IKK- (2370), or anti-p65 (8242) (Cell Signaling Technology, Danvers, MA) antibodies
Accordingly, we hypothesized that inhibition of RNR function may suppress ferroptosis by reducing the draw on the existing GSH pool, which can then be re-routed to suppress ferroptosis
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